Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease

Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is an incurable neurodegenerative disease currently affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying common genetic variants driving differences in transcript expression that confer AD risk is necessary to elucidat...

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Bibliographic Details
Main Authors: Jake Gockley, Kelsey S. Montgomery, William L. Poehlman, Jesse C. Wiley, Yue Liu, Ekaterina Gerasimov, Anna K. Greenwood, Solveig K. Sieberts, Aliza P. Wingo, Thomas S. Wingo, Lara M. Mangravite, Benjamin A. Logsdon
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Medicine
Subjects:
Alzheimer’s disease
TWAS
FUSION
GWAS
Dementia
Neurodegeneration
Online Access:https://doi.org/10.1186/s13073-021-00890-2

Internet

https://doi.org/10.1186/s13073-021-00890-2

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