Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

Oxidative stress is a well-established event in the pathology of several neurobiological diseases. Sirt3 is a nicotinamide adenine nucleotide (NAD+)-dependent protein deacetylase that regulates mitochondrial function and metabolism in response to caloric restriction and stress. This study aims to in...

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Bibliographic Details
Main Authors: Shu-Hui Dai, Tao Chen, Yu-Hai Wang, Jie Zhu, Peng Luo, Wei Rao, Yue-Fan Yang, Zhou Fei, Xiao-Fan Jiang
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
Sirt3
oxidative stress
mitochondria
Ca2+
mitochondrial biogenesis
Online Access:http://www.mdpi.com/1422-0067/15/8/14591

Internet

http://www.mdpi.com/1422-0067/15/8/14591

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