Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1

Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by a non-coding CTG repeat expansion in the DMPK gene. This mutation generates a toxic CUG RNA that interferes with the RNA processing of target genes in multiple tissues. Despite debilitating neurological impairment, the pathophysio...

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Bibliographic Details
Main Authors: Anchel González-Barriga, Louison Lallemant, Diana M. Dincã, Sandra O. Braz, Hélène Polvèche, Paul Magneron, Cédric Pionneau, Aline Huguet-Lachon, Jean-Baptiste Claude, Cerina Chhuon, Ida Chiara Guerrera, Cyril F. Bourgeois, Didier Auboeuf, Geneviève Gourdon, Mário Gomes-Pereira
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
myotonic dystrophy
neurons
astrocytes
oligodendrocytes
transcriptomics
phosphoproteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.662035/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.662035/full

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