Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates.

Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates.

In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction. Axonal clustering of mammalian voltage-gated sodium and KCNQ (Kv7) potassium channels is based on linkage to the actin-spectrin cyto...

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Bibliographic Details
Main Authors: Alexis S Hill, Atsuo Nishino, Koichi Nakajo, Giuxin Zhang, Jaime R Fineman, Michael E Selzer, Yasushi Okamura, Edward C Cooper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2597720?pdf=render

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http://europepmc.org/articles/PMC2597720?pdf=render

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