3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain

3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain

We isolated a pol inhibitor from the cultured mycelia extract of a fungal strain isolated from natural salt from a sea salt pan in Australia, which was identified as 3-O-methylfunicone by spectroscopic analyses. This compound selectively inhibited the activities of mammalian Y-family DNA polymerases...

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Bibliographic Details
Main Authors: Fumio Sugawara, Hiromi Yoshida, Ken Hirano, Toshifumi Takeuchi, Yasuhiro Yamaguchi, Yoshiyuki Mizushina, Hirohisa Motoshima
Format: Article
Language:English
Published: MDPI AG 2009-11-01
Series:Marine Drugs
Subjects:
3-O-methylfunicone
Y-family DNA polymerase
DNA polymerase κ
enzyme inhibitor
marine fungal strains
Australian sea salt
anti-cancer drug
Online Access:http://www.mdpi.com/1660-3397/7/4/624/

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http://www.mdpi.com/1660-3397/7/4/624/

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