IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren’s Syndrome Patients

IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren’s Syndrome Patients

ObjectiveTo investigate the role of IL-2 in the balance of Th17 and Tregs and elucidate the underlying mechanisms of enhanced Th17 differentiation in primary Sjögren’s syndrome (pSS) patients.MethodsThis study involved 31 pSS patients, 7 Sicca patients, and 31 healthy subjects. Th17 and Treg cells w...

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Bibliographic Details
Main Authors: Jing Luo, Bingxia Ming, Cai Zhang, Xiaofei Deng, Pingfei Li, Zhengping Wei, Yu Xia, Kan Jiang, Hong Ye, Wanli Ma, Zheng Liu, Huabin Li, Xiang-Ping Yang, Lingli Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
Sjögren syndrome
IL-2
Treg
Th17
p-STAT5
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01755/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01755/full

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