Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

Human cystatin C (HCC), a cysteine-protease inhibitor, exists as a folded monomer under physiological conditions but has the ability to self-assemble via domain swapping into multimeric states, including oligomers with a doughnut-like structure. The structure of the monomeric HCC has been solved by...

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Bibliographic Details
Main Authors: Magdalena Chrabąszczewska, Adam K. Sieradzan, Sylwia Rodziewicz-Motowidło, Anders Grubb, Christopher M. Dobson, Janet R. Kumita, Maciej Kozak
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
cystatin C
oligomers
domain swapping
protein misfolding
Online Access:https://www.mdpi.com/1422-0067/21/16/5860

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https://www.mdpi.com/1422-0067/21/16/5860

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