MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL

MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL

Abstract Background While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained is limited. DNA methyltransferases and ten-eleven translocation methylcytosine dioxygenases (TETs) function has been found...

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Bibliographic Details
Main Authors: Candace J. Poole, Atul Lodh, Jeong-Hyeon Choi, Jan van Riggelen
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Epigenetics & Chromatin
Subjects:
MYC
TET1
TET2
DNA methylation
DNA hydroxymethylation
Leukemia/lymphoma
Online Access:http://link.springer.com/article/10.1186/s13072-019-0278-5

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http://link.springer.com/article/10.1186/s13072-019-0278-5

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