Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced b...

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Bibliographic Details
Main Authors: Kai Zhang, Naqi Lian, Ran Ding, Cunle Guo, Xi Dong, Yuanyuan Li, Sheng Wei, Qingyan Jiao, Yonghao Yu, Hui Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
isoflurane
sleep deprivation
short-term memory
long-term memory
Ca2+ signals
dendritic spine
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2020.589176/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2020.589176/full

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