Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of <i>Salmonella enterica</i> Serovar Typhimurium Infection

Cytokine-Mediated Regulation of ARG1 in Macrophages and Its Impact on the Control of <i>Salmonella enterica</i> Serovar Typhimurium Infection

Arginase 1 (ARG1) is a cytosolic enzyme that cleaves L-arginine, the substrate of inducible nitric oxide synthase (iNOS), and thereby impairs the control of various intracellular pathogens. Herein, we investigated the role of ARG1 during infection with <i>Salmonella enterica</i> serovar...

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Bibliographic Details
Main Authors: Natascha Brigo, Christa Pfeifhofer-Obermair, Piotr Tymoszuk, Egon Demetz, Sabine Engl, Marina Barros-Pinkelnig, Stefanie Dichtl, Christine Fischer, Lara Valente De Souza, Verena Petzer, Laura von Raffay, Richard Hilbe, Sylvia Berger, Markus Seifert, Ulrike Schleicher, Christian Bogdan, Günter Weiss
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
arginase 1
inducible nitric oxide synthase
<i>Salmonella enterica</i> serovar Typhimurium
macrophages
intracellular bacteria
Online Access:https://www.mdpi.com/2073-4409/10/7/1823

Internet

https://www.mdpi.com/2073-4409/10/7/1823

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