Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.

The transcription factor NF-κB is essential for immune responses against pathogens and its activation requires the phosphorylation, ubiquitination and proteasomal degradation of IκBα. Here we describe an inhibitor of NF-κB from vaccinia virus that has a closely related counterpart in variola virus,...

Full description

Bibliographic Details
Main Authors: Daniel S Mansur, Carlos Maluquer de Motes, Leonie Unterholzner, Rebecca P Sumner, Brian J Ferguson, Hongwei Ren, Pavla Strnadova, Andrew G Bowie, Geoffrey L Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3585151?pdf=render

Internet

http://europepmc.org/articles/PMC3585151?pdf=render

Similar Items