Modular design of artificial tissue homeostasis: robust control through synthetic cellular heterogeneity.

Modular design of artificial tissue homeostasis: robust control through synthetic cellular heterogeneity.

Synthetic biology efforts have largely focused on small engineered gene networks, yet understanding how to integrate multiple synthetic modules and interface them with endogenous pathways remains a challenge. Here we present the design, system integration, and analysis of several large scale synthet...

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Bibliographic Details
Main Authors: Miles Miller, Marc Hafner, Eduardo Sontag, Noah Davidsohn, Sairam Subramanian, Priscilla E M Purnick, Douglas Lauffenburger, Ron Weiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3400602?pdf=render

Internet

http://europepmc.org/articles/PMC3400602?pdf=render

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