NRF2 -617 C/A Polymorphism Impacts Proinflammatory Cytokine Levels, Survival, and Transplant-Related Mortality After Hematopoietic Stem Cell Transplantation in Adult Patients Receiving Busulfan-Based Conditioning Regimens

NRF2 -617 C/A Polymorphism Impacts Proinflammatory Cytokine Levels, Survival, and Transplant-Related Mortality After Hematopoietic Stem Cell Transplantation in Adult Patients Receiving Busulfan-Based Conditioning Regimens

Busulfan (BU) is widely used in conditioning regimens prior to hematopoietic stem cell transplantation (HSCT). The exposure-escalated BU directed by therapeutic drug monitoring (TDM) is extremely necessary for the patients with high-risk hematologic malignancies in order to diminish relapse, but it...

Full description

Bibliographic Details
Main Authors: Jingjing Huang, Chenxia Hao, Ziwei Li, Ling Wang, Jieling Jiang, Wei Tang, Lining Wang, Weixia Zhang, Jiong Hu, Wanhua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
busulfan
polymorphism
proinflammatory
transplant-related mortality
NF-E2-related factor 2 (Nrf2)
hematopoietic stem cell transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.563321/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.563321/full

Similar Items