Core regulatory circuitries in defining cancer cell identity across the malignant spectrum

Core regulatory circuitries in defining cancer cell identity across the malignant spectrum

Gene expression programmes driving cell identity are established by tightly regulated transcription factors that auto- and cross-regulate in a feed-forward manner, forming core regulatory circuitries (CRCs). CRC transcription factors create and engage super-enhancers by recruiting acetylation writer...

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Bibliographic Details
Main Authors: Leila Jahangiri, Loukia Tsaprouni, Ricky M. Trigg, John A. Williams, Georgios V. Gkoutos, Suzanne D. Turner, Joao Pereira
Format: Article
Language:English
Published: The Royal Society 2020-07-01
Series:Open Biology
Subjects:
core regulatory circuitry
liquid and solid cancers
super-enhancers
cell identity
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200121

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200121

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