Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance

Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance

Colorectal cancer is a leading cause of cancer deaths. Most colorectal cancer patients eventually develop chemoresistance to the current standard-of-care therapies. Here, we used patient-derived colorectal cancer organoids to demonstrate that resistant tumor cells undergo significant chromatin chang...

Full description

Bibliographic Details
Main Authors: Kuei-Ling Tung, Kai-Yuan Chen, Marcos Negrete, Tianyi Chen, Alexias Safi, Abed Alhalim Aljamal, Lingyun Song, Gregory E. Crawford, Shengli Ding, David S. Hsu, Xiling Shen
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Genes and Diseases
Subjects:
Chromatin accessibility
Drug screening
Patient-derived organoids
Personalized medicine
Target discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304219300996

Internet

http://www.sciencedirect.com/science/article/pii/S2352304219300996

Similar Items