Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model

Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model

The present study has planned to evaluate the neuroprotective activity of two novel glitazones in a neuroinflammatory rat model. Two novel glitazones were selected from an in-house virtual library of glitazones based on their docking scores against peroxisome proliferator-activated receptor-gamma (P...

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Bibliographic Details
Main Authors: Antony Justin, Premkumar Ashwini, Jincy A. Jose, Victoria Jeyarani, S. P. Dhanabal, Chennu Manisha, Subhankar P. Mandal, Guru Bhavimani, P. Prabitha, S. Yuvaraj, B. R. Prashantha Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neuroscience
Subjects:
neuroinflammation
PPAR-γ
glitazones
PGC-1α
cytokines
anti-oxidant
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.530148/full

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https://www.frontiersin.org/article/10.3389/fnins.2020.530148/full

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