Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice

Minimal-length Synthetic shRNAs Formulated with Lipid Nanoparticles are Potent Inhibitors of Hepatitis C Virus IRES-linked Gene Expression in Mice

We previously identified short synthetic shRNAs (sshRNAs) that target a conserved hepatitis C virus (HCV) sequence within the internal ribosome entry site (IRES) of HCV and potently inhibit HCV IRES-linked gene expression. To assess in vivo liver delivery and activity, the HCV-directed sshRNA, SG220...

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Bibliographic Details
Main Authors: Anne Dallas, Heini Ilves, Joshua Shorenstein, Adam Judge, Ryan Spitler, Christopher Contag, Suet Ping Wong, Richard P Harbottle, Ian MacLachlan, Brian H Johnston
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
HCV
lipid nanoparticles
PK
RNAi
shRNA
sshRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301822

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http://www.sciencedirect.com/science/article/pii/S2162253116301822

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