Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells

Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells

Abstract Background Thousands of mammalian promoters are defined by co-enrichment of the histone tail modifications H3K27me3 (repressive) and H3K4me3 (activating) and are thus termed bivalent. It was previously observed that bivalent genes in human ES cells (hESC) are frequent targets for hypermethy...

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Bibliographic Details
Main Authors: Donnchadh S. Dunican, Heidi K. Mjoseng, Leanne Duthie, Ilya M. Flyamer, Wendy A. Bickmore, Richard R. Meehan
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Biology
Subjects:
DNA methylation
Polycomb
Bivalent
Epigenetic
Chromatin
Development
Online Access:http://link.springer.com/article/10.1186/s12915-020-0752-3

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http://link.springer.com/article/10.1186/s12915-020-0752-3

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