SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

Abstract Background S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that specifically recognizes phosphorylated cell cycle regulator proteins and mediates their ubiquitination. Programmed cell death protein 4 (PDCD4) is a tumor suppressor gene that plays a role in...

Full description

Bibliographic Details
Main Authors: Ce Li, Lutao Du, Yidan Ren, Xiaoyan Liu, Qinlian Jiao, Donghai Cui, Mingxin Wen, Chuanxin Wang, Guangwei Wei, Yunshan Wang, Aiguo Ji, Qin Wang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
SKP2
PDCD4
Cell apoptosis
DNA-damage response
Radiotherapy
Online Access:http://link.springer.com/article/10.1186/s13046-019-1069-3

Internet

http://link.springer.com/article/10.1186/s13046-019-1069-3

Similar Items