Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry granulation (MADG) process. There are no reports in the literature...

Full description

Bibliographic Details
Main Authors: Alhussain H. Aodah, Mohamed H. Fayed, Ahmed Alalaiwe, Bader B. Alsulays, Mohammed F. Aldawsari, El-Sayed Khafagy
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pharmaceutics
Subjects:
metformin hydrochloride
orally disintegrating tablet (ODT)
quality-by-design (QbD)
moisture activated dry granulation (MADG)
high drug loading
Online Access:https://www.mdpi.com/1999-4923/12/7/598

Internet

https://www.mdpi.com/1999-4923/12/7/598

Similar Items