Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions

Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions

In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human...

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Bibliographic Details
Main Authors: Guilherme A. M. Jardim, Daisy J. B. Lima, Wagner O. Valença, Bruno C. Cavalcanti, Claudia Pessoa, Jamal Rafique, Antonio L. Braga, Claus Jacob, Eufrânio N. da Silva Júnior, Eduardo H. G. da Cruz
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
lapachol
naphthoquinone
cancer
selenium
click chemistry
C-H activation
Online Access:https://www.mdpi.com/1420-3049/23/1/83

Internet

https://www.mdpi.com/1420-3049/23/1/83

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