Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.

Chemical-genetic interactions-observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes-contain rich functional information linking compounds to their cellular modes of action. To systematically identify these interactions, an array of mutants is challenged wi...

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Bibliographic Details
Main Authors: Scott W Simpkins, Justin Nelson, Raamesh Deshpande, Sheena C Li, Jeff S Piotrowski, Erin H Wilson, Abraham A Gebre, Hamid Safizadeh, Reika Okamoto, Mami Yoshimura, Michael Costanzo, Yoko Yashiroda, Yoshikazu Ohya, Hiroyuki Osada, Minoru Yoshida, Charles Boone, Chad L Myers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC6226211?pdf=render

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http://europepmc.org/articles/PMC6226211?pdf=render

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