Identification of Theaflavin-3,3’-Digallate as a Novel Zika Virus Protease Inhibitor

Identification of Theaflavin-3,3’-Digallate as a Novel Zika Virus Protease Inhibitor

Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological disorders such as microcephaly and Guillain-Barré syndrome. There are currently no effective vaccines and FDA-approved inhibitors against ZIKV infection. The flaviviral heterodimeric serine protease NS2B-NS3 plays...

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Bibliographic Details
Main Authors: Xiangling Cui, Rui Zhou, Chenchao Huang, Rongyu Zhang, Jing Wang, Yongxin Zhang, Jiwei Ding, Xiaoyu Li, Jinming Zhou, Shan Cen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
Zika virus
natural active compound
screen
anti-virus
protease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.514313/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.514313/full

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