Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus

Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus

Abstract Background PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The PDE4 isoform PDE4B1 also interacts with the DIS...

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Bibliographic Details
Main Authors: Susan L. Campbell, Thomas van Groen, Inga Kadish, Lisa High Mitchell Smoot, Graeme B. Bolger
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Neuroscience
Subjects:
Learning
Memory
Depression
PKA
CREB
DISC1
Online Access:http://link.springer.com/article/10.1186/s12868-017-0396-6

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http://link.springer.com/article/10.1186/s12868-017-0396-6

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