HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the mitochondrion resulting in reduced FA beta ox...

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Bibliographic Details
Main Authors: Weinan Du, Luchang Zhang, Adina Brett-Morris, Brittany Aguila, Janos Kerner, Charles L. Hoppel, Michelle Puchowicz, Dolors Serra, Laura Herrero, Brian I. Rini, Steven Campbell, Scott M. Welford
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01965-8

Internet

https://doi.org/10.1038/s41467-017-01965-8

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