Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions

Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions

Unlike cerebellin 1 (Cbln1), which bridges neurexin (Nrxn) receptors and δ-type glutamate receptors in a trans-synaptic triad, Cbln4 was reported to have no or weak binding for the receptors despite sharing ∼70% sequence identity with Cbln1. Here, we report crystal structures of the homotrimers of t...

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Bibliographic Details
Main Authors: Chen Zhong, Jinlong Shen, Huibing Zhang, Guangyi Li, Senlin Shen, Fang Wang, Kuan Hu, Longxing Cao, Yongning He, Jianping Ding
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
Cbln1
Cbln4
C1q domain
C1q/TNF superfamily
neurexin
receptor specificity
synaptogenesis
Nrxn1β
synapse
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311385

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http://www.sciencedirect.com/science/article/pii/S2211124717311385

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