Hypoxia Predicts Poor Prognosis in Neuroblastoma Patients and Associates with Biological Mechanisms Involved in Telomerase Activation and Tumor Microenvironment Reprogramming

Hypoxia Predicts Poor Prognosis in Neuroblastoma Patients and Associates with Biological Mechanisms Involved in Telomerase Activation and Tumor Microenvironment Reprogramming

The biological and clinical heterogeneity of neuroblastoma (NB) demands novel biomarkers and therapeutic targets in order to drive the most appropriate treatment for each patient. Hypoxia is a condition of low-oxygen tension occurring in poorly vascularized tumor tissues. In this study, we aimed to...

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Bibliographic Details
Main Authors: Davide Cangelosi, Martina Morini, Nicolò Zanardi, Angela Rita Sementa, Marco Muselli, Massimo Conte, Alberto Garaventa, Ulrich Pfeffer, Maria Carla Bosco, Luigi Varesio, Alessandra Eva
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
neuroblastoma
hypoxia
prognosis
cell immortalization
therapeutic target
Online Access:https://www.mdpi.com/2072-6694/12/9/2343

Internet

https://www.mdpi.com/2072-6694/12/9/2343

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