c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study

c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study

Relationships between c-Rel and GCB-DLBCLs remain unclear. We found that strong c-Rel DNA-binding activity was mostly found in GCBs on two independent series of 48 DLBCLs and 66 DLBCLs, the latter issued from the GHEDI series. c-Rel DNA-binding activity was associated with increased REL mRNA express...

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Bibliographic Details
Main Authors: Nathalie Faumont, Oussama Taoui, Davi Collares, Jean-Philippe Jais, Karen Leroy, Léa Prévaud, Fabrice Jardin, Thierry J. Molina, Christiane Copie-Bergman, Barbara Petit, Marie-Pierre Gourin, Dominique Bordessoule, Danielle Troutaud, Véronique Baud, Jean Feuillard
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
NF-kappaB
DNA binding activity
c-Rel
germinal center B-cell–diffuse large B-cell lymphoma
genetic alterations
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.638897/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.638897/full

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