Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study

Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study

(E)-Methyl-4-aryl-4-oxabut-2-enoate (YH-8) is a novel PKnB protein kinase inhibitor with good anti-tuberculosis activity. To evaluate its pharmacokinetics in rats, a sensitive and selective high performance liquid chromatography–tandem mass spectrometric (LC--MS/MS) method has been developed and val...

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Bibliographic Details
Main Authors: Qianqian Zhai, Jing Pang, Guoqing Li, Congran Li, Xinyi Yang, Liyan Yu, Yucheng Wang, Jian Li, Xuefu You
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
YH-8
LC–MS/MS
Pharmacokinetics
Rat plasma
Method validation
Online Access:http://www.sciencedirect.com/science/article/pii/S221138351500074X

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http://www.sciencedirect.com/science/article/pii/S221138351500074X

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