Development of an in vitro media perfusion model of Leishmania major macrophage infection.

<h4>Background</h4>In vitro assays are widely used in studies on pathogen infectivity, immune responses, drug and vaccine discovery. However, most in vitro assays display significant differences to the in vivo situation and limited predictive properties. We applied medium perfusion metho...

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Bibliographic Details
Main Authors: Alec O'Keeffe, Lauren Hyndman, Sean McGinty, Alaa Riezk, Sudaxshina Murdan, Simon L Croft
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0219985