Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells

Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells

The Wnt/b-catenin signaling pathway is abnormally activated in most colorectal cancers and in a proportion of other neoplasias. This activation initiates or contributes to carcinogenesis by regulating the expression of a large number of genes in tumor cells. The active vitamin D metabolite 1a,25-dih...

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Bibliographic Details
Main Authors: Alberto Muñoz, Gemma Ferrer-Mayorga, Núria Niell, María Jesús Larriba, Antonio Barbáchano, José Manuel González-Sancho
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Cancers
Subjects:
vitamin D
1a,25-dihydroxyvitamin D3
Wnt
b-catenin
colon cancer
vitamin D receptor
Online Access:http://www.mdpi.com/2072-6694/5/4/1242

Internet

http://www.mdpi.com/2072-6694/5/4/1242

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