Monocyte-Derived Dendritic Cells Differentiated in the Presence of Lenalidomide Display a Semi-Mature Phenotype, Enhanced Phagocytic Capacity, and Th1 Polarization Capability

Monocyte-Derived Dendritic Cells Differentiated in the Presence of Lenalidomide Display a Semi-Mature Phenotype, Enhanced Phagocytic Capacity, and Th1 Polarization Capability

Lenalidomide is an analog of thalidomide, with potent anticancer activity demonstrated in several hematological malignancies. It has immunomodulatory properties, being able to enhance the activation of different types of immune cells, which results in antitumor activities. Dendritic cells (DCs) are...

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Bibliographic Details
Main Authors: Juan López-Relaño, Beatriz Martín-Adrados, Irene Real-Arévalo, Javier Lozano-Bartolomé, Beatriz Abós, Silvia Sánchez-Ramón, Bárbara Alonso, Manuel Gómez del Moral, Eduardo Martínez-Naves
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
lenalidomide
dendritic cells
antigen presentation
phagocytosis
NKT cell
T-cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01328/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01328/full

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