Diabetes Induces a Transcriptional Signature in Bone Marrow–Derived CD34<sup>+</sup> Hematopoietic Stem Cells Predictive of Their Progeny Dysfunction

Diabetes Induces a Transcriptional Signature in Bone Marrow–Derived CD34<sup>+</sup> Hematopoietic Stem Cells Predictive of Their Progeny Dysfunction

Hematopoietic stem/progenitor cells (HSPCs) participate in cardiovascular (CV) homeostasis and generate different types of blood cells including lymphoid and myeloid cells. Diabetes mellitus (DM) is characterized by chronic increase of pro-inflammatory mediators, which play an important role in the...

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Bibliographic Details
Main Authors: Yuri D’Alessandra, Mattia Chiesa, Vera Vigorelli, Veronica Ricci, Erica Rurali, Angela Raucci, Gualtiero Ivanoe Colombo, Giulio Pompilio, Maria Cristina Vinci
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes
bone marrow
hematopoietic stem cells
CD34<sup>+</sup>, transcriptional profile
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/3/1423

Internet

https://www.mdpi.com/1422-0067/22/3/1423

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