Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.

The loss of HIV-specific CD8+ T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8+ T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8+ T cell functio...

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Bibliographic Details
Main Authors: Korey R Demers, George Makedonas, Marcus Buggert, Michael A Eller, Sarah J Ratcliffe, Nilu Goonetilleke, Chris K Li, Leigh Anne Eller, Kathleen Rono, Lucas Maganga, Sorachai Nitayaphan, Hannah Kibuuka, Jean-Pierre Routy, Mark K Slifka, Barton F Haynes, Andrew J McMichael, Nicole F Bernard, Merlin L Robb, Michael R Betts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4972399?pdf=render

Internet

http://europepmc.org/articles/PMC4972399?pdf=render

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