Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

Summary: T helper 17 (Th17) cell development is programmed by the orphan nuclear receptor RORγt, but the underlying mechanism is not well understood. Nuclear receptor-mediated transcriptional activation depends on coactivators. Here, we show that steroid receptor coactivator-3 (SRC-3) critically reg...

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Bibliographic Details
Main Authors: Kentaro Tanaka, Gustavo J. Martinez, Xiaowei Yan, Weiwen Long, Kenji Ichiyama, Xinxin Chi, Byung-Seok Kim, Joseph M. Reynolds, Yeonseok Chung, Shinya Tanaka, Lan Liao, Yoichi Nakanishi, Akihiko Yoshimura, Pan Zheng, Xiaohu Wang, Qiang Tian, Jianming Xu, Bert W. O’Malley, Chen Dong
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718306661

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http://www.sciencedirect.com/science/article/pii/S2211124718306661

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