Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition

Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition

Guanylate Cyclase activating protein 1 (GCAP1) mediates the Ca<sup>2+</sup>-dependent regulation of the retinal Guanylate Cyclase (GC) in photoreceptors, acting as a target inhibitor at high [Ca<sup>2+</sup>] and as an activator at low [Ca<sup>2+</sup>]. Recently,...

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Bibliographic Details
Main Authors: Seher Abbas, Valerio Marino, Laura Bielefeld, Karl-Wilhelm Koch, Daniele Dell’Orco
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
cone dystrophy
neuronal calcium sensor
retinal guanylate cyclase
guanylate cyclase-activating protein 1
Online Access:https://www.mdpi.com/1422-0067/21/3/752

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https://www.mdpi.com/1422-0067/21/3/752

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