Intrastriatal Administration of Exosome-Associated Pathological Alpha-Synuclein Is Not Sufficient by Itself to Cause Pathology Transmission

Intrastriatal Administration of Exosome-Associated Pathological Alpha-Synuclein Is Not Sufficient by Itself to Cause Pathology Transmission

α-Synuclein (α-syn) has been genetically and biochemically linked to the pathogenesis of Parkinson’s disease (PD). There is accumulating evidence that misfolded α-syn species spread between cells in a prion-like manner and seed the aggregation of endogenous protein in the recipient cells. Exosomes h...

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Bibliographic Details
Main Authors: Mantia Karampetsou, Vasia Samantha Sykioti, Emmanouela Leandrou, Katerina Melachroinou, Alexandros Lambiris, Antonis Giannelos, Evangelia Emmanouilidou, Kostas Vekrellis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein (a-synuclein)
propagation
exosomes
Parkinson’s
aggregation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00246/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00246/full

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