TCR/pMHC interaction: phenotypic model for an unsolved enigma

TCR/pMHC interaction: phenotypic model for an unsolved enigma

TCR-pMHC interaction is the keystone of the adaptive immune response.This process exhibits animpressive capacity of speed, sensitivity and discrimination thatallows to detect foreign pMHCs at very low concentration amongmuch more abundant self-pMHC ligands.However, and despite over three decades of...

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Bibliographic Details
Main Authors: Jesus Galvez, Juan J. Galvez, Pilar Garcia-Peñarrubia
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Kinetic proofreading
TCR activation
stabilization and destabilization of TCR/pMHC complexes
dissociation and propagation rate constants
activation chain
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00467/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00467/full

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