MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here the authors find that protein phosphatase 1 and its regulatory subunit PNUTS controls MYC stability and its interaction with chromatin.

Bibliographic Details
Main Authors: Dharmendra Dingar, William B. Tu, Diana Resetca, Corey Lourenco, Aaliya Tamachi, Jason De Melo, Kathleen E. Houlahan, Manpreet Kalkat, Pak-Kei Chan, Paul C. Boutros, Brian Raught, Linda Z. Penn
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05660-0

Internet

https://doi.org/10.1038/s41467-018-05660-0

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