Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups

Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups

Acyltransferase domains (ATs) of polyketide synthases (PKSs) are critical for loading of acyl groups on acyl carrier protein domains (A) via self- and trans-acylation reactions, to produce structurally diverse polyketides. However, the interaction specificity between ATs and unusual acyl units is ra...

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Bibliographic Details
Main Authors: Jie-Jie Shen, Fu Chen, Xiao-Xuan Wang, Xiao-Fang Liu, Xin-Ai Chen, Xu-Ming Mao, Yong-Quan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
AT
allmal-CoA
ethmal-CoA
self- and trans-acylation
substrate specificity
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01840/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01840/full

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