Alteration of Cholesterol Metabolism by Metformin Is Associated With Improved Outcome in Type II Diabetic Patients With Diffuse Large B-Cell Lymphoma

Alteration of Cholesterol Metabolism by Metformin Is Associated With Improved Outcome in Type II Diabetic Patients With Diffuse Large B-Cell Lymphoma

Recent studies have demonstrated the benefits of metformin on patients with lymphomas. B-cell receptor (BCR)-PI3K-AKT pathway-dependent cholesterol synthesis may represent a positive feedback mechanism responsible for the pathogenesis of BCR-dependent diffuse large B-cell lymphomas (DLBCLs). Thus, r...

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Bibliographic Details
Main Authors: Xiang-Nan Jiang, Yan Zhang, Wei-Ge Wang, Dong Sheng, Xiao-Yan Zhou, Xiao-Qiu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
metformin
cholesterol
diffuse large B-cell lymphoma
B-cell receptor
type II diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.608238/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.608238/full

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