Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein

Background: Vascular endothelial cells activation and dysfunction mediate inflammation and abnormal coagulation in COVID-19 patients. Mineralocorticoid receptor (MR) signaling and its downstream target Galectin-3 (Gal-3) are known to mediate cardiovascular inflammation and might be involved in the p...

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Bibliographic Details
Main Authors: Eva Jover, Lara Matilla, Mattie Garaikoetxea, Amaya Fernández-Celis, Pieter Muntendam, Frédéric Jaisser, Patrick Rossignol, Natalia López-Andrés
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
SARS-CoV2
Spike
endothelial cells
inflammation
mineralocorticoid receptor
Online Access:https://www.mdpi.com/2227-9059/9/6/639

Internet

https://www.mdpi.com/2227-9059/9/6/639

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