Protective Effects of Gomisin N against Hepatic Cannabinoid Type 1 Receptor-Induced Insulin Resistance and Gluconeogenesis

Protective Effects of Gomisin N against Hepatic Cannabinoid Type 1 Receptor-Induced Insulin Resistance and Gluconeogenesis

Activation of the hepatic cannabinoid type 1 receptor (CB1R) induces insulin resistance and gluconeogenesis via endoplasmic reticulum (ER) stress, thereby contributing to hyperglycemia. Gomisin N (GN) is a phytochemical derived from Schisandra chinensis. In the current study, we investigated the inh...

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Bibliographic Details
Main Authors: Arulkumar Nagappan, Dae Young Jung, Ji-Hyun Kim, Myeong Ho Jung
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
cannabinoid type 1 receptor
endoplasmic reticulum stress
gluconeogenesis
gomisin N
lipogenesis
insulin resistance
Online Access:http://www.mdpi.com/1422-0067/19/4/968

Internet

http://www.mdpi.com/1422-0067/19/4/968

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