CHARACTERIZATION OF PROTEIN-PROTEIN INTERFACES THROUGH A PROTEIN-CONTACT-NETWORK APPROACH

CHARACTERIZATION OF PROTEIN-PROTEIN INTERFACES THROUGH A PROTEIN-CONTACT-NETWORK APPROACH

Anthrax toxin comprises of three different proteins, jointly acting to exert toxic activity: a non-toxic protective agent (PA), toxic edema factor (EF) and lethal factor (LF). Binding of PA to anthrax receptors promotes oligomerization of PA, binding of EF and LF, then endocytosis of the complex. Ho...

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Bibliographic Details
Main Authors: Luisa eDi Paola, Chiara Bianca Maria Platania, Gabriele eOliva, Roberto eSetola, Federica ePascucci, Alessandro eGiuliani
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Proteins
protein-protein interactions
network resilience
Anthrax toxin
Protein Contact Networks
Online Access:http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00170/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00170/full

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