Gene-Related Cerebellar Neurodegeneration in SCA3/MJD: A Case-Controlled Imaging-Genetic Study

Gene-Related Cerebellar Neurodegeneration in SCA3/MJD: A Case-Controlled Imaging-Genetic Study

Background: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is one of the nine polyglutamine (polyQ) diseases and is caused by a CAG repeat expansion within the coding sequence of the ATXN3 gene. Few multimodal imaging analyses of the macro- and micro-structural changes have been per...

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Bibliographic Details
Main Authors: Huirong Peng, Xiaochun Liang, Zhe Long, Zhao Chen, Yuting Shi, Kun Xia, Li Meng, Beisha Tang, Rong Qiu, Hong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neurology
Subjects:
spinocerebellar ataxia 3
gray matter
white matter
1HMRS
imaging genetics study
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01025/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.01025/full

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