Role for the IFT-A Complex in Selective Transport to the Primary Cilium
Intraflagellar transport sub-complex A (IFT-A) is known to regulate retrograde IFT in the cilium. To rigorously assess its other possible roles, we knocked out an IFT-A subunit, IFT121/WDR35, in mammalian cells and screened the localization of more than 50 proteins. We found that Wdr35 regulates cil...
Main Authors: | Wenxiang Fu, Lei Wang, Sehyun Kim, Ji Li, Brian David Dynlacht |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-11-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124716314048 |
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