4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studies

4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studies

Abstract A series of novel 4-thiazolidinone inhibitors SKYa–SKYg, containing coumarin as a core structure were synthesized via facile and efficient method. The structures of the synthesized compounds were established by extensive spectroscopic studies (FT IR, 1D NMR, 2D NMR, LC–MS) and elemental ana...

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Bibliographic Details
Main Authors: Samina Khan Yusufzai, Hasnah Osman, Mohammad Shaheen Khan, Basma M. Abd Razik, Mohammed Oday Ezzat, Suriyati Mohamad, Othman Sulaiman, Jualang Azlan Gansau, Thaigarajan Parumasivam
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Chemistry Central Journal
Subjects:
Molecular docking
Anti-bacterial
Anti-tuberculosis
Anti-viral
Anti-dengue
Coumarin thiazolidinone
Online Access:http://link.springer.com/article/10.1186/s13065-018-0435-0

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http://link.springer.com/article/10.1186/s13065-018-0435-0

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