PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity

PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity

T follicular helper (Tfh) cells are a specialized population of CD4+ T cells that provide help to B cells for the formation and maintenance germinal centers, and the production of high affinity class-switched antibodies, long-lived plasma cells, and memory B cells. As such, Tfh cells are essential f...

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Bibliographic Details
Main Authors: Silvia Preite, Bonnie Huang, Jennifer L. Cannons, Dorian B. McGavern, Pamela L. Schwartzberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
Tfh cells
Tfr
ICOS
PI3K
APDS
PASLI
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03079/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03079/full

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