Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity.

Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity.

In our studies of ovarian cancer cells we have identified subpopulations of cells that are in a transitory E/M hybrid stage, i.e. cells that simultaneously express epithelial and mesenchymal markers. E/M cells are not homogenous but, in vitro and in vivo, contain subsets that can be distinguished ba...

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Main Authors: Robert Strauss, Zong-Yi Li, Ying Liu, Ines Beyer, Jonas Persson, Pavel Sova, Thomas Möller, Sari Pesonen, Akseli Hemminki, Petra Hamerlik, Charles Drescher, Nicole Urban, Jiri Bartek, André Lieber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3021543?pdf=render

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http://europepmc.org/articles/PMC3021543?pdf=render

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