Plasma-Based Longitudinal Evaluation of ESR1 Epigenetic Status in Hormone Receptor-Positive HER2-Negative Metastatic Breast Cancer

Plasma-Based Longitudinal Evaluation of ESR1 Epigenetic Status in Hormone Receptor-Positive HER2-Negative Metastatic Breast Cancer

BackgroundEndocrine therapy (ET) is the mainstay of treatment for hormone receptor-positive human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer; however, adaptive mechanisms emerge in about 25–30% of cases through alterations in the estrogen receptor ligand-binding doma...

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Bibliographic Details
Main Authors: Lorenzo Gerratana, Debora Basile, Alessandra Franzoni, Lorenzo Allegri, Davide Viotto, Carla Corvaja, Lucia Bortot, Elisa Bertoli, Silvia Buriolla, Giada Targato, Lucia Da Ros, Stefania Russo, Marta Bonotto, Barbara Belletti, Gustavo Baldassarre, Giuseppe Damante, Fabio Puglisi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
circulating tumor DNA
DNA methylation
endocrine treatment
ESR1
liquid biopsy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.550185/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.550185/full

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